Publications

Articles in high-impact, peer-reviewed scientific journals

New England Journal of Medicine
Science Translational Medicine
The Lancet

American Journal of Respiratory & Critical Care Medicine
Journal of Allergy and Clinical Immunology

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Selected CIC publications of note. Click on the covers for details.


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Refereed Journal Articles

The databases below list refereed journal articles that have emerged from the Clinical Investigator Collaborative (CIC).

One database lists articles relating to clinical trials; the other lists articles related to other mechanistic work of CIC. Click on the corresponding tab to view either category of publication.

The databases can be sorted and/or searched by different data fields. When searching by author, use last name only.

Clinical trialsOther
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Total Records Found: 15, showing 100 per page
Author(s)YearTitleJournal
Gauvreau GM, FitzGerald JM, Boulet L-P, Watson R, Hui L, Villeneuve H, Scime T, Schlatman A, Obminski C, Kum J, Boehme S, Ly TW, Bacon K, O'Byrne PM 2018 The Effects of a CCR3 Inhibitor, AXP1275, on Allergen-Induced Airway Responses in Adults with Mild-to Moderate Atopic Asthma Clinical & Experimental Allergy
Gauvreau GM, Boulet LP, Leigh R, Cockcroft DW, Davis BE, Mayers I et al. 2016

Efficacy and safety of multiple doses of QGE031 (ligelizumab) versus omalizumab and placebo in inhibiting allergen-induced early asthmatic responses

Journal of Allergy and Clinical Immunology

Todd CM, Salter BM, Murphy DM, Watson RM, Howie KJ, Milot J, Sadeh J, Boulet LP, O'Byrne PM, Gauvreau GM 2016

The effects of a CXCR1/CXCR2 antagonist on neutrophil migration in mild atopic asthmatic subjects

Pulmonary Pharmacology and Therapeutics

Gauvreau GM, Boulet LP, FitzGerald JM, Cockcroft DW, Davis BE, Leigh R, Tanaka M, Fourre JA, Tanaka M, Nabata T, O'Byrne PM 2016

A dual CysLT1/2 antagonist attenuates allergen-induced airway responses in subjects with mild allergic asthma

Allergy

Boulet LP, Gauvreau GM, Cockcroft DW, Davis B, Vachon L, Cormier Y, O'Byrne PM 2015

Effects of ASM-024, a modulator of acetylcholine receptor function, on airway responsiveness and allergen-induced responses in patients with mild asthma

Canadian Respiratory Journal

Gauvreau GM, Boulet LP, Leigh R, Cockcroft DW, Killian KJ, Davis BE, Deschesnes F, Watson RM, Swystun V, Mårdh CK, Wessman P, Jorup C, Aurivillius M, O'Byrne PM 2015

A nonsteroidal glucocorticoid receptor agonist inhibits allergen-induced late asthmatic responses

American Journal of Respiratory and Critical Care Medicine

Watson BM, Oliveria JP, Nusca GM, Smith SG, Beaudin S, Dua B, Watson RM, Assayag EI, Cormier YF, Sehmi R, Gauvreau GM 2015

Inhibition of allergen-induced basophil activation by ASM-024, a nicotinic receptor ligand

International Archives of Allergy and Immunology

Gauvreau GM, Harris JM, Boulet LP, Sheerens H, FitzGerald JM, Putnam WS, Cockcroft DW, Davis BE, Leigh R, Zheng Y, Dahlén B, Wang Y, Maciuca R, Mayers I, Liao XC, Wu LC, Matthews JG, O'Byrne PM. 2014

Targeting membrane-expressed IgE B cell receptor with an antibody to the M1 prime epitope reduces IgE production

Science Translational Medicine

Gauvreau GM, O'Byrne PM, Boulet L-P, Wang Y, Cockcroft DW, Bigler J, FitzGerald JM, Boedigheimer M, Davis BE, Dias C, Gorski KS, Smith L, Bautista E, Comeau MR, Leigh R, Parnes JR. 2014

Effects of an Anti-TSLP Antibody on Allergen-Induced Asthmatic Responses

The New England Journal of Medicine

Gauvreau GM, Boulet L-P, Cockcroft DW, FitzGerald JM, Mayers I, Carlsten C, Laviolette M, Killian KJ, Davis BE, Larché M , Kipling C , Dua B , Mosesova S , Putnam W , Zheng Y, Scheerens H, McClintock D , Matthews J, O'Byrne PM 2014

OX40L blockade on allergen-induced airway responses in subjects with mild asthma

Clinical Experimental Allergy

Gauvreau GM, Boulet LP, Cockcroft DW, Fitzgerald JM, Carlsten C, Davis BE, Deschesnes F, Duong M, Durn BL, Howie KJ, Hui L, Kasaian MT, Killian KJ, Strinich TX, Watson RM, Y N, Zhou S, Raible D, O'Byrne PM. 2011

The effects of IL-13 blockade on allergen-induced airway responses in mild atopic asthma

American Journal of Respiratory and Critical Care Medicine

Davis BE, Illamperuma C, Gauvreau GM, Watson RM, O'Byrne PM, Deschesnes F, Boulet LP, Cockcroft DW. 2009

Single dose desloratadine and montelukast and allergen-induced late airway responses

European Respiratory Journal

O'Byrne PM, van der Linde J, Cockcroft DW, Gauvreau GM, Brannan JD, FitzGerald JM, Watson RM, Milot J, Davis B, O?Connor M, Hart L, Korducki L, Hamilton J. 2009 Prolonged bronchoprotection against inhaled methacholine by inhaled BI 1744, a long-acting β2-agonist, in mild asthmatics

Journal of Allergy and Clinical Immunology

Gauvreau GM, Boulet L-P, Cockcroft DW, Baatjes A, Cote J, Deschesnes F, Davis B, Strinich T, Howie K, Duong M, Watson RM, Renzi PM, O'Byrne, PM. 2008 Antisense therapy against CCR3 and the common beta chain attenuates allergen-induced eosinophilic responses

American Journal of Respiratory and Critical Care Medicine

Duong M, Cockcroft D, Boulet L-P, Ahmed T, Iverson H, Atkinson D, Stahl E, Watson R, Davis B, Milo J, Gauvreau G, O'Byrne P. 2008

The effect of IVX-0142, a heparin-derived hypersulfated disaccharide, on the allergic airway responses in asthma

Allergy

Total Records Found: 60, showing 100 per page
Author(s)YearTitleJournal
Tang W, Smith SG, Du W, Gugilla A, Du J, Oliveria JP, Howie K, Salter BM, Gauvreau GM, O'Byrne PM, Sehmi R 2018 Interleukin-25 and eosinophils progenitor cell mobilization in allergic asthma Clinical Translational Allergy
Al-Sajee D, Oliveria JP, Sehmi R, Gauvreau GM 2018 Antialarmins for treatment of asthma: future perspectives Current Opinion in Pulmonary Medicine
Revez JA, Killian KJ, O'Byrne PM, Boulet LP, Upham JW, Gauvreau GM, Ferreira MAR 2018 Sputum cytology during late-phase responses to inhalation challenge with different allergens Allergy
Salter BMA, Smith SG, Mukherjee M, Plante S, Krisna S, Nusca G, Oliveria JP, Irshad A, Gauvreau GM, Chakir J, Nair P, Sehmi R 2018 Human Bronchial Epithelial Cell-derived Factors from Severe Asthmatic Subjects Stimulate Eosinophil Differentiation American Journal of Respiratory and Critical Care Medicine
Lawson JA, Rennie DC, Cockcroft DW, Dyck R, Afanasieva A, Oluwole O, Afsana J. 2017 Childhood asthma, asthma severity indicators, and related conditions along an urban-rural gradient: a cross-sectional study</a BMC Pulmonary Medicine
Lok SD, Davis BE, Cockcroft DW 2017 Prevalence of allergen sensitization in 1000 adults in Saskatchewan Allergy, Asthma & Clinical Immunology
Tavakoli H, FitzGerald JM, Chen W, Lynd L, Kendzerska T, Aaron S, Gershon A, Marra C, Sadatsafavi M; Canadian Respiratory Research Network. 2017 Ten-year trends in direct costs of asthma: a population-based study Allergy
Oluwole O, Kirychuk SP, Lawson JA, Karunanayake C, Cockcroft DW, Willson PJ, Senthilselvan A, Rennie DC. 2017 Indoor mold levels and current asthma among school-aged children in Saskatchewan, Canada Indoor Air
O’Byrne P. M. FitzGerald JM, Zhong, N et al. 2017 The SYGMA programme of phase 3 trials to evaluate the efficacy and safety of budesonide/formoterol given as needed in mild asthma: study protocols for two randomised controlled trials

Trials
Nolin JD, Lai Y, Ogden HL, Manicone AM, Murphy RC, An D, Frevert CW, Ghomashchi F, Naika GS, Gelb MH, Gauvreau GM, Piliponsky AM, Altemeier WA, Hallstrand TS 2017 Secreted PLA2 group X orchestrates innate and adaptive immune responses to inhaled allergen JCI Insight
Chen R, Smith SG, Salter B, El-Gammal A, Oliviria JP, Obminski C, Watson R, O'Byrne PM, Gauvreau GM, Sehmi R. 2017 Allergen-induced Increases in Sputum Levels of Group 2 Innate Lymphoid Cells in Subjects with Asthma American Journal of Respiratory and Critical Care Medicine
Coates AL, Wanger J, Cockcroft DW, Culver BH, Carlsen K-H, Diamant Z, Enright P, Gauvreau G, Hall GL, Hallstrand TS, Horvath I, deJongh FHC, Joos G, Kaminsky DA, Laube BL, Leuppi JD, Sterk PJ 2017 ERS technical standard on bronchial challenge testing: general considerations and performance of methacholine challenge tests European Respiratory Journal
Blais C, Cockcroft DW, Veilleux J, Boulay ME, Boulet L-P, Gauvreau GM, Scime TX, Watson RM, O’Byrne PM, Davis BE 2017 Methacholine challenge: comparison of airway responsiveness produced by a vibrating mesh nebulizer versus a jet nebulizer Journal of Aerosol Medicine and Pulmonary Drug Delivery
Mitchell PD, Salter BM, Oliveria JP, El-Gammal A, Tworek D, Smith SG, Sehmi R, Gauvreau GM, Butler M, O'Byrne PM 2016

Glucagon Like Peptide-1 receptor expression on human eosinophils and its regulation of eosinophil activation

Clinical and Experimental Allergy

Tang W, Smith SG, Salter B, Oliveria JP, Mitchell P, Nusca GM, Howie K, Gauvreau GM, O'Byrne PM, Sehmi R 2016

Allergen-Induced Increases in Interleukin-25 and Interleukin-25 Receptor Expression in Mature Eosinophils from Atopic Asthmatics</stron

International Archives of Allergy and Immunology

Salter BM, Manzoor F, Beaudin S, Kjarsgaard M, Nair P, Gauvreau GM, Sehmi R 2016

Dysregulation of Vascular Endothelial Progenitor Cells Lung-Homing in Subjects with COPD

Canadian Respiratory Journal

El-Gammal A, Oliveria JP, Howie K, Watson R, Mitchell P, Chen R, Baatjes A, Smith S, Al-Sajee D, Hawke TJ, Killian KJ, Gauvreau GM, O'Byrne PM 2016

Allergen-induced Changes in Bone Marrow and Airway Dendritic Cells in Subjects with Asthma

American Journal of Respiratory and Critical Care Medicine

Salter BM, Oliveria JP, Nusca G, Smith SG, Tworek D, Mitchell PD, Watson RM, Sehmi R, Gauvreau GM 2016

IL-25 and IL-33 induce Type 2 inflammation in basophils from subjects with allergic asthma

Respiratory Research

Tworek D, Smith SG, Salter BM, Baatjes AJ, Scime T, Watson R, Obminski C, Gauvreau GM, O'Byrne PM 2016

IL-25 Receptor Expression on Airway Dendritic Cells after Allergen Challenge in Subjects with Asthma

American Journal of Respiratory and Critical Care Medicine

Sadatsafavi M, Chen W, Tavakoli H, Rolf JD, Rousseau R, FitzGerald JM 2016 Economic Burden of Asthma Study Group. Saving in medical costs by achieving guideline-based asthma symptom control: a population-based study

Allergy
Kerstjens HAM, O'Byrne PM 2016 Tiotropium for the treatment of asthma: a drug safety evaluation Expert Opinion on Drug Safety
Cockcroft DW 2016 Giants in allergy-immunology: Frederick E. “Freddy” Hargreave, MB ChB, MD Annals of Allergy, Asthma & Immunology
Silkoff PE, Laviolette M, Singh D, FitzGerald JM, Kelsen S, Backer V, Porsbjerg C, Girodet PO, Berger P, Kline JN, Khatri S, Chanez P, Susulic VS, Barnathan ES, Baribaud F, Loza MJ; ADEPT Investigators. 2016 Longitudinal stability of asthma characteristics and biomarkers from the Airways Disease Endotyping for Personalized Therapeutics (ADEPT) study

Respiratory Research
Mitchell PD, O'Byrne PM 2016 Surfactant protein-D and asthma CHEST
FitzGerald JM, Sadatsafavi M. 2016 Less chaos in the prognosis of asthma-chronic obstructive lung disease overlap The Lancet Respiratory Medicine
Ehteshami-Afshar S, FitzGerald JM, Carlsten C, Tavakoli H, Rousseau R, Tan WC, Rolf JD, Sadatsafavi M. 2016 The impact of comorbidities on productivity loss in asthma patients Respiratory Research
Wong A, Tavakoli H, Sadatsafavi M, Carlsten C, FitzGerald JM. 2016 Asthma control and productivity loss in those with work-related asthma: a population-based study Journal of Asthma
Blais CM, Davis BE, Cockcroft DW. 2016 Duration of bronchoprotection of the long-acting muscarinic antagonists tiotropium & glycopyrronium against methacholineinduced bronchoconstriction in mild asthmatics

Respiratory Medicine
Nair P, O'Byrne PM 2016 Measuring Eosinophils to Make Treatment Decisions in Asthma CHEST
O'Byrne PM, Metev H, Puu M, Richter K, Keen C, Uddin M, Larsson B, Cullberg M, Nair P. 2016 Efficacy and safety of a CXCR2 antagonist, AZD5069, in patients with uncontrolled persistent asthma: a randomised, double-blind, placebo-controlled trial

The Lancet Respiratory Medicine
O'Byrne PM, Jacques L, Goldfrad C, Kwon N-H, Perrio M, Yates LJ, Busse WW. 2016 Integrated safety and efficacy analysis of once-daily fluticasone furoate for the treatment of asthma Respiratory Research
Sadatsafavi M, Tavakoli H, Lynd L, FitzGerald JM 2016 Has asthma medication use caught up with the evidence? CHEST
Wang H, Chen R, Xie J, Zhang Q, Deng Y, Zeng Q, Zhu Z, Ding M, Lai Z, Kolb M, O'Byrne P, Chen R, Zhong N. 2016 A 43-year-old man with cough, expectoration and recurrent wheezing Journal of Thoracic Disease
Poureslami I, Shum J, Nimmon L, FitzGerald JM. 2016 Culturally Specific Evaluation of Inhaler Techniques in Asthma Respiratory Care
Chen W, Lynd LD, FitzGerald JM, Marra CA, Balshaw R, To T, Tavakoli H, Sadatsafavi M. Canadian Respiratory Research Network. 2016 Excess medical costs in patients with asthma and the role of comorbidity European Respiratory Journal
Bleecker ER, FitzGerald JM, Chanez P, Papi A, Weinstein SF, Barker P, Sproule S, Gilmartin G, Aurivillius M, Werkström V, Goldman M; SIROCCO study investigators. 2016

Efficacy and safety of benralizumab for patients with severe asthma uncontrolled with high-dosage inhaled corticosteroids and long-acting β2-agonists (SIROCCO): a randomised, multicentre, placebo-controlled phase 3 trial

The Lancet
FitzGerald JM, Bleecker ER, Nair P, Korn S, Ohta K, Lommatzsch M, Ferguson GT, Busse WW, Barker P, Sproule S, Gilmartin G, Werkström V, Aurivillius M, Goldman M; CALIMA study investigators 2016 Benralizumab, an anti-interleukin-5 receptor α monoclonal antibody, as add-on treatment for patients with severe, uncontrolled, eosinophilic asthma (CALIMA): a randomised, double-blind, placebo-controlled phase 3 trial

The Lancet
Smith SG, Chen R, Kjarsgaard M, Huang C, Oliveria JP, O'Byrne P, Gauvreau G, Boulet L-P, Lemiere C, Martin JG, Nair P, Sehmi R. 2015

Increased numbers of activated group 2 innate lymphoid cells in the airways of patients with severe asthma and persistent airway eosinophilia

Journal of Allergy & Clinical Immunology

Boulet LP, Gauvreau G, Boulay ME, O'Byrne P, Cockcroft DW 2015

Allergen-induced early and late asthmatic responses to inhaled seasonal and perennial allergens

Clinical & Experimental Allergy

Olfert J, Gjevre J,Cockcroft D. 2015

A nonallergic mechanism for nut-induced wheeze

Journal of Allergy and Clinical Immunology: In Practice

Davis BE, Amakye DO, Cockcroft DW 2015

Airway responsiveness to mannitol 24 hours after 7b allergen challenge in atopic asthmatics

Allergy

Janssen LJ, Gauvreau GM, Killian KJ, O'Byrne PM 2015

The Effects of Repeated Bronchoprovocation on FEV1 in Subjects with Asthma

Annals of the American Thoracic Society

Salter BM, Oliveria JP, Nusca G, Smith SG, Watson RM, Comeau M, Sehmi R, Gauvreau GM 2015

Thymic stromal lymphopoietin activation of basophils in patients with allergic asthma is IL-3 dependent

Journal of Allergy and Clinical Immunology

El-Gammal AI, Killian KJ, Scime TX, Beaudin S, Schlatman A, Cockcroft DW, Gauvreau GM 2015

Comparison of the provocative concentration of methacholine causing a 20% fall in FEV1 between the AeroEclipse II breath-actuated nebulizer and the wright nebulizer in adult subjects with Asthma

Annals of the American Thoracic Society

Smith SG, Gugilla A, Mukherjee M, Merim K, Irshad A, Tang W, Kinoshita T, Watson B, Oliveria JP, Comeau M, O'Byrne PM, Gauvreau GM, Sehmi R 2015 Thymic stromal lymphopoietin and IL-33 modulate migration of hematopoietic progenitor cells in patients with allergic asthma

Journal of Allergy and Clinical Immunology

Mitchell PD, El-Gammal AI, O'Byrne PM 2015 Emerging monoclonal antibodies as targeted innovative therapeutic approaches to asthma Clinical Pharmacology and Therapeutics
Jones NL, O'Byrne P. 2014

Respiratory Medicine at McMaster University, Hamilton, Ontario: 1698 to 2013

Canadian Respiratory Journal

Nataraj RTY,Cockcroft DW, Fladeland DA. 2014

An uncommon cause of wheeze

Journal of Allergy and Clinical Immunology: In Practice

Davis BE, Stewart SL, Martin AL, Cockcroft DW. 2014 Low levels of fractional exhaled nitric oxide and deep inhalation bronchoprotection are associated with mannitol non-responsiveness in asthma

Respiratory Medicine

Singh A, Yamamoto M, Kam SHY, Ruan J, Gauvreau GM, O'Byrne PM, FitzGerald JM, Schellenberg R, Boulet L-P, Wojewodka G, Kanagaratham C, De Sanctis J, Radzioch D, Tebbutt SJ. 2013

Gene-metabolite expression in blood can discriminate allergen-induced isolated early from dual asthmatic responses

PLOS ONE

Davidson WJ, Wong LE, The S, Leigh R. 2013

The impact of diurnal variation on induced sputum cell counts in healthy adults

Clinical and Translational Allergy

Kam SHY, Singh A, He J-Q, Ruan J, Gauvreau GM, O'Byrne PM, FitzGerald JM, Tebbutt SJ. 2012

Peripheral blood gene expression changes during allergen inhalation challenge in atopic asthmatic individuals

Journal of Asthma

Singh A, Cohen Freue GV, Oosthuizen JL, Kam SHY, Ruan J, Takhar M, Gauvreau GM, O'Byrne PM, FitzGerald JM, Boulet L-P, Borchers CH, Tebbutt SJ. 2012 Plasma proteomics can discriminate isolated early from dual responses in asthmatic individuals undergoing an allergen inhalation challenge

Proteomics ? Clinical Applications

Yamamoto M, Singh A, Ruan J, Gauvreau GM, O'Byrne PM, Carlsten C, FitzGerald JM, Boulet L-P, Tebbutt SJ. 2012

Decreased miR-192 expression in peripheral blood of asthmatic individuals undergoing an allergen inhalation challenge

BMC Genomics

Lougheed MD, Lemière C, Ducharme FM, Lickai C, Dell SD, Rowe BH, Fitzgerald M, Leigh R, Watson W, Boulet L-P. 2012 Canadian Thoracic Society 2012 Guideline Update: Diagnosis and Management of Asthma in Preschoolers, Children and Adults: Executive Summary

Canadian Respiratory Journal

Davenport MH, Beaudin AE, Brown AD, Leigh R, Poulin MJ. 2012

Ventilatory responses to exercise and CO2 after menopause in healthy women: effects of age and fitness

Respiratory Physiology & Neurobiology

Fitzgerald M. 2012

Randomised controlled trial: In two parallel pragmatic equivalence trials, leukotriene receptor antagonists as initial therapy

Evidence-Based Medicine for Primary Care and Internal Medicine

Peters GE, Davis BE, Cockcroft DW. 2011

Characterization of the methacholine PC15

Annals of Allergy, Asthma & Immunology

Kelly MM, King EM, Rider CF, Gwozd C, Holden NS, Eddleston J, Zuraw B, Leigh R, O'Byrne PM, Newton R. 2011

Corticosteroid-induced gene expression in allergen-challenged asthmatic subjects taking inhaled budesonide</

British Journal of Pharmacology

O'Byrne PM, Gauvreau GM, Murphy DM 2009

Efficacy of leukotriene receptor antagonists and synthesis inhibitors in asthma

Journal of Allergy and Clinical Immunology

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