Articles in high-impact, peer-reviewed scientific journals
Science Translational Medicine
The LancetAmerican Journal of Respiratory & Critical Care Medicine
Journal of Allergy and Clinical Immunology
Selected CIC publications of note. Click on the covers for details.
Refereed Journal Articles
The databases below list refereed journal articles that have emerged from the Clinical Investigator Collaborative (CIC).
One database lists articles relating to clinical trials; the other lists articles related to other mechanistic work of CIC. To view either category of publication, click on the corresponding tab.
The databases can be sorted and/or searched by different data fields. When searching by author, use last name only.
| Author(s) | Year | Title | Journal |
|---|---|---|---|
| Gauvreau GM, FitzGerald JM, Boulet L-P, Watson R, Hui L, Villeneuve H, Scime T, Schlatman A, Obminski C, Kum J, Boehme S, Ly TW, Bacon K, O'Byrne PM | 2018 | The Effects of a CCR3 Inhibitor, AXP1275, on Allergen-Induced Airway Responses in Adults with Mild-to Moderate Atopic Asthma | Clinical & Experimental Allergy |
| Gauvreau GM, Boulet LP, Leigh R, Cockcroft DW, Davis BE, Mayers I et al. | 2016 |
Journal of Allergy and Clinical Immunology |
|
| Todd CM, Salter BM, Murphy DM, Watson RM, Howie KJ, Milot J, Sadeh J, Boulet LP, O'Byrne PM, Gauvreau GM | 2016 |
The effects of a CXCR1/CXCR2 antagonist on neutrophil migration in mild atopic asthmatic subjects |
Pulmonary Pharmacology and Therapeutics |
| Gauvreau GM, Boulet LP, FitzGerald JM, Cockcroft DW, Davis BE, Leigh R, Tanaka M, Fourre JA, Tanaka M, Nabata T, O'Byrne PM | 2016 |
Allergy |
|
| Boulet LP, Gauvreau GM, Cockcroft DW, Davis B, Vachon L, Cormier Y, O'Byrne PM | 2015 |
Canadian Respiratory Journal |
|
| Gauvreau GM, Boulet LP, Leigh R, Cockcroft DW, Killian KJ, Davis BE, Deschesnes F, Watson RM, Swystun V, Mårdh CK, Wessman P, Jorup C, Aurivillius M, O'Byrne PM | 2015 |
A nonsteroidal glucocorticoid receptor agonist inhibits allergen-induced late asthmatic responses |
American Journal of Respiratory and Critical Care Medicine |
| Watson BM, Oliveria JP, Nusca GM, Smith SG, Beaudin S, Dua B, Watson RM, Assayag EI, Cormier YF, Sehmi R, Gauvreau GM | 2015 |
Inhibition of allergen-induced basophil activation by ASM-024, a nicotinic receptor ligand |
International Archives of Allergy and Immunology |
| Gauvreau GM, Harris JM, Boulet LP, Sheerens H, FitzGerald JM, Putnam WS, Cockcroft DW, Davis BE, Leigh R, Zheng Y, Dahlén B, Wang Y, Maciuca R, Mayers I, Liao XC, Wu LC, Matthews JG, O'Byrne PM. | 2014 |
Science Translational Medicine |
|
| Gauvreau GM, O'Byrne PM, Boulet L-P, Wang Y, Cockcroft DW, Bigler J, FitzGerald JM, Boedigheimer M, Davis BE, Dias C, Gorski KS, Smith L, Bautista E, Comeau MR, Leigh R, Parnes JR. | 2014 |
Effects of an Anti-TSLP Antibody on Allergen-Induced Asthmatic Responses |
The New England Journal of Medicine |
| Gauvreau GM, Boulet L-P, Cockcroft DW, FitzGerald JM, Mayers I, Carlsten C, Laviolette M, Killian KJ, Davis BE, Larché M , Kipling C , Dua B , Mosesova S , Putnam W , Zheng Y, Scheerens H, McClintock D , Matthews J, O'Byrne PM | 2014 |
OX40L blockade on allergen-induced airway responses in subjects with mild asthma |
Clinical Experimental Allergy |
| Gauvreau GM, Boulet LP, Cockcroft DW, Fitzgerald JM, Carlsten C, Davis BE, Deschesnes F, Duong M, Durn BL, Howie KJ, Hui L, Kasaian MT, Killian KJ, Strinich TX, Watson RM, Y N, Zhou S, Raible D, O'Byrne PM. | 2011 |
The effects of IL-13 blockade on allergen-induced airway responses in mild atopic asthma |
American Journal of Respiratory and Critical Care Medicine |
| Davis BE, Illamperuma C, Gauvreau GM, Watson RM, O'Byrne PM, Deschesnes F, Boulet LP, Cockcroft DW. | 2009 |
Single dose desloratadine and montelukast and allergen-induced late airway responses |
European Respiratory Journal |
| O'Byrne PM, van der Linde J, Cockcroft DW, Gauvreau GM, Brannan JD, FitzGerald JM, Watson RM, Milot J, Davis B, O?Connor M, Hart L, Korducki L, Hamilton J. | 2009 | Prolonged bronchoprotection against inhaled methacholine by inhaled BI 1744, a long-acting β2-agonist, in mild asthmatics |
Journal of Allergy and Clinical Immunology |
| Gauvreau GM, Boulet L-P, Cockcroft DW, Baatjes A, Cote J, Deschesnes F, Davis B, Strinich T, Howie K, Duong M, Watson RM, Renzi PM, O'Byrne, PM. | 2008 | Antisense therapy against CCR3 and the common beta chain attenuates allergen-induced eosinophilic responses |
American Journal of Respiratory and Critical Care Medicine |
| Duong M, Cockcroft D, Boulet L-P, Ahmed T, Iverson H, Atkinson D, Stahl E, Watson R, Davis B, Milo J, Gauvreau G, O'Byrne P. | 2008 |
Allergy |
| Author(s) | Year | Title | Journal |
|---|---|---|---|
| Tang W, Smith SG, Du W, Gugilla A, Du J, Oliveria JP, Howie K, Salter BM, Gauvreau GM, O'Byrne PM, Sehmi R | 2018 | Interleukin-25 and eosinophils progenitor cell mobilization in allergic asthma | Clinical Translational Allergy |
| Al-Sajee D, Oliveria JP, Sehmi R, Gauvreau GM | 2018 | Antialarmins for treatment of asthma: future perspectives | Current Opinion in Pulmonary Medicine |
| Revez JA, Killian KJ, O'Byrne PM, Boulet LP, Upham JW, Gauvreau GM, Ferreira MAR | 2018 | Sputum cytology during late-phase responses to inhalation challenge with different allergens | Allergy |
| Salter BMA, Smith SG, Mukherjee M, Plante S, Krisna S, Nusca G, Oliveria JP, Irshad A, Gauvreau GM, Chakir J, Nair P, Sehmi R | 2018 | Human Bronchial Epithelial Cell-derived Factors from Severe Asthmatic Subjects Stimulate Eosinophil Differentiation | American Journal of Respiratory and Critical Care Medicine |
| Lawson JA, Rennie DC, Cockcroft DW, Dyck R, Afanasieva A, Oluwole O, Afsana J. | 2017 | Childhood asthma, asthma severity indicators, and related conditions along an urban-rural gradient: a cross-sectional study</a | BMC Pulmonary Medicine |
| Lok SD, Davis BE, Cockcroft DW | 2017 | Prevalence of allergen sensitization in 1000 adults in Saskatchewan | Allergy, Asthma & Clinical Immunology |
| Tavakoli H, FitzGerald JM, Chen W, Lynd L, Kendzerska T, Aaron S, Gershon A, Marra C, Sadatsafavi M; Canadian Respiratory Research Network. | 2017 | Ten-year trends in direct costs of asthma: a population-based study | Allergy |
| Oluwole O, Kirychuk SP, Lawson JA, Karunanayake C, Cockcroft DW, Willson PJ, Senthilselvan A, Rennie DC. | 2017 | Indoor mold levels and current asthma among school-aged children in Saskatchewan, Canada | Indoor Air |
| O’Byrne P. M. FitzGerald JM, Zhong, N et al. | 2017 | The SYGMA programme of phase 3 trials to evaluate the efficacy and safety of budesonide/formoterol given as needed in mild asthma: study protocols for two randomised controlled trials | Trials |
| Nolin JD, Lai Y, Ogden HL, Manicone AM, Murphy RC, An D, Frevert CW, Ghomashchi F, Naika GS, Gelb MH, Gauvreau GM, Piliponsky AM, Altemeier WA, Hallstrand TS | 2017 | Secreted PLA2 group X orchestrates innate and adaptive immune responses to inhaled allergen | JCI Insight |
| Chen R, Smith SG, Salter B, El-Gammal A, Oliviria JP, Obminski C, Watson R, O'Byrne PM, Gauvreau GM, Sehmi R. | 2017 | Allergen-induced Increases in Sputum Levels of Group 2 Innate Lymphoid Cells in Subjects with Asthma | American Journal of Respiratory and Critical Care Medicine |
| Coates AL, Wanger J, Cockcroft DW, Culver BH, Carlsen K-H, Diamant Z, Enright P, Gauvreau G, Hall GL, Hallstrand TS, Horvath I, deJongh FHC, Joos G, Kaminsky DA, Laube BL, Leuppi JD, Sterk PJ | 2017 | ERS technical standard on bronchial challenge testing: general considerations and performance of methacholine challenge tests | European Respiratory Journal |
| Blais C, Cockcroft DW, Veilleux J, Boulay ME, Boulet L-P, Gauvreau GM, Scime TX, Watson RM, O’Byrne PM, Davis BE | 2017 | Methacholine challenge: comparison of airway responsiveness produced by a vibrating mesh nebulizer versus a jet nebulizer | Journal of Aerosol Medicine and Pulmonary Drug Delivery |
| Mitchell PD, Salter BM, Oliveria JP, El-Gammal A, Tworek D, Smith SG, Sehmi R, Gauvreau GM, Butler M, O'Byrne PM | 2016 |
Clinical and Experimental Allergy |
|
| Tang W, Smith SG, Salter B, Oliveria JP, Mitchell P, Nusca GM, Howie K, Gauvreau GM, O'Byrne PM, Sehmi R | 2016 |
International Archives of Allergy and Immunology |
|
| Salter BM, Manzoor F, Beaudin S, Kjarsgaard M, Nair P, Gauvreau GM, Sehmi R | 2016 |
Dysregulation of Vascular Endothelial Progenitor Cells Lung-Homing in Subjects with COPD |
Canadian Respiratory Journal |
| El-Gammal A, Oliveria JP, Howie K, Watson R, Mitchell P, Chen R, Baatjes A, Smith S, Al-Sajee D, Hawke TJ, Killian KJ, Gauvreau GM, O'Byrne PM | 2016 |
Allergen-induced Changes in Bone Marrow and Airway Dendritic Cells in Subjects with Asthma |
American Journal of Respiratory and Critical Care Medicine |
| Salter BM, Oliveria JP, Nusca G, Smith SG, Tworek D, Mitchell PD, Watson RM, Sehmi R, Gauvreau GM | 2016 |
IL-25 and IL-33 induce Type 2 inflammation in basophils from subjects with allergic asthma |
Respiratory Research |
| Tworek D, Smith SG, Salter BM, Baatjes AJ, Scime T, Watson R, Obminski C, Gauvreau GM, O'Byrne PM | 2016 |
IL-25 Receptor Expression on Airway Dendritic Cells after Allergen Challenge in Subjects with Asthma |
American Journal of Respiratory and Critical Care Medicine |
| Sadatsafavi M, Chen W, Tavakoli H, Rolf JD, Rousseau R, FitzGerald JM | 2016 | Economic Burden of Asthma Study Group. Saving in medical costs by achieving guideline-based asthma symptom control: a population-based study | Allergy |
| Kerstjens HAM, O'Byrne PM | 2016 | Tiotropium for the treatment of asthma: a drug safety evaluation | Expert Opinion on Drug Safety |
| Cockcroft DW | 2016 | Giants in allergy-immunology: Frederick E. “Freddy” Hargreave, MB ChB, MD | Annals of Allergy, Asthma & Immunology |
| Silkoff PE, Laviolette M, Singh D, FitzGerald JM, Kelsen S, Backer V, Porsbjerg C, Girodet PO, Berger P, Kline JN, Khatri S, Chanez P, Susulic VS, Barnathan ES, Baribaud F, Loza MJ; ADEPT Investigators. | 2016 | Longitudinal stability of asthma characteristics and biomarkers from the Airways Disease Endotyping for Personalized Therapeutics (ADEPT) study | Respiratory Research |
| Mitchell PD, O'Byrne PM | 2016 | Surfactant protein-D and asthma | CHEST |
| FitzGerald JM, Sadatsafavi M. | 2016 | Less chaos in the prognosis of asthma-chronic obstructive lung disease overlap | The Lancet Respiratory Medicine |
| Ehteshami-Afshar S, FitzGerald JM, Carlsten C, Tavakoli H, Rousseau R, Tan WC, Rolf JD, Sadatsafavi M. | 2016 | The impact of comorbidities on productivity loss in asthma patients | Respiratory Research |
| Wong A, Tavakoli H, Sadatsafavi M, Carlsten C, FitzGerald JM. | 2016 | Asthma control and productivity loss in those with work-related asthma: a population-based study | Journal of Asthma |
| Blais CM, Davis BE, Cockcroft DW. | 2016 | Duration of bronchoprotection of the long-acting muscarinic antagonists tiotropium & glycopyrronium against methacholineinduced bronchoconstriction in mild asthmatics | Respiratory Medicine |
| Nair P, O'Byrne PM | 2016 | Measuring Eosinophils to Make Treatment Decisions in Asthma | CHEST |
| O'Byrne PM, Metev H, Puu M, Richter K, Keen C, Uddin M, Larsson B, Cullberg M, Nair P. | 2016 | Efficacy and safety of a CXCR2 antagonist, AZD5069, in patients with uncontrolled persistent asthma: a randomised, double-blind, placebo-controlled trial | The Lancet Respiratory Medicine |
| O'Byrne PM, Jacques L, Goldfrad C, Kwon N-H, Perrio M, Yates LJ, Busse WW. | 2016 | Integrated safety and efficacy analysis of once-daily fluticasone furoate for the treatment of asthma | Respiratory Research |
| Sadatsafavi M, Tavakoli H, Lynd L, FitzGerald JM | 2016 | Has asthma medication use caught up with the evidence? | CHEST |
| Wang H, Chen R, Xie J, Zhang Q, Deng Y, Zeng Q, Zhu Z, Ding M, Lai Z, Kolb M, O'Byrne P, Chen R, Zhong N. | 2016 | A 43-year-old man with cough, expectoration and recurrent wheezing | Journal of Thoracic Disease |
| Poureslami I, Shum J, Nimmon L, FitzGerald JM. | 2016 | Culturally Specific Evaluation of Inhaler Techniques in Asthma | Respiratory Care |
| Chen W, Lynd LD, FitzGerald JM, Marra CA, Balshaw R, To T, Tavakoli H, Sadatsafavi M. Canadian Respiratory Research Network. | 2016 | Excess medical costs in patients with asthma and the role of comorbidity | European Respiratory Journal |
| Bleecker ER, FitzGerald JM, Chanez P, Papi A, Weinstein SF, Barker P, Sproule S, Gilmartin G, Aurivillius M, Werkström V, Goldman M; SIROCCO study investigators. | 2016 | The Lancet | |
| FitzGerald JM, Bleecker ER, Nair P, Korn S, Ohta K, Lommatzsch M, Ferguson GT, Busse WW, Barker P, Sproule S, Gilmartin G, Werkström V, Aurivillius M, Goldman M; CALIMA study investigators | 2016 | Benralizumab, an anti-interleukin-5 receptor α monoclonal antibody, as add-on treatment for patients with severe, uncontrolled, eosinophilic asthma (CALIMA): a randomised, double-blind, placebo-controlled phase 3 trial | The Lancet |
| Smith SG, Chen R, Kjarsgaard M, Huang C, Oliveria JP, O'Byrne P, Gauvreau G, Boulet L-P, Lemiere C, Martin JG, Nair P, Sehmi R. | 2015 |
Journal of Allergy & Clinical Immunology |
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| Boulet LP, Gauvreau G, Boulay ME, O'Byrne P, Cockcroft DW | 2015 |
Allergen-induced early and late asthmatic responses to inhaled seasonal and perennial allergens |
Clinical & Experimental Allergy |
| Olfert J, Gjevre J,Cockcroft D. | 2015 |
Journal of Allergy and Clinical Immunology: In Practice |
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| Davis BE, Amakye DO, Cockcroft DW | 2015 |
Airway responsiveness to mannitol 24 hours after 7b allergen challenge in atopic asthmatics |
Allergy |
| Janssen LJ, Gauvreau GM, Killian KJ, O'Byrne PM | 2015 |
The Effects of Repeated Bronchoprovocation on FEV1 in Subjects with Asthma |
Annals of the American Thoracic Society |
| Salter BM, Oliveria JP, Nusca G, Smith SG, Watson RM, Comeau M, Sehmi R, Gauvreau GM | 2015 |
Journal of Allergy and Clinical Immunology |
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| El-Gammal AI, Killian KJ, Scime TX, Beaudin S, Schlatman A, Cockcroft DW, Gauvreau GM | 2015 |
Annals of the American Thoracic Society |
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| Smith SG, Gugilla A, Mukherjee M, Merim K, Irshad A, Tang W, Kinoshita T, Watson B, Oliveria JP, Comeau M, O'Byrne PM, Gauvreau GM, Sehmi R | 2015 | Thymic stromal lymphopoietin and IL-33 modulate migration of hematopoietic progenitor cells in patients with allergic asthma |
Journal of Allergy and Clinical Immunology |
| Mitchell PD, El-Gammal AI, O'Byrne PM | 2015 | Emerging monoclonal antibodies as targeted innovative therapeutic approaches to asthma | Clinical Pharmacology and Therapeutics |
| Jones NL, O'Byrne P. | 2014 |
Respiratory Medicine at McMaster University, Hamilton, Ontario: 1698 to 2013 |
Canadian Respiratory Journal |
| Nataraj RTY,Cockcroft DW, Fladeland DA. | 2014 |
Journal of Allergy and Clinical Immunology: In Practice |
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| Davis BE, Stewart SL, Martin AL, Cockcroft DW. | 2014 | Low levels of fractional exhaled nitric oxide and deep inhalation bronchoprotection are associated with mannitol non-responsiveness in asthma |
Respiratory Medicine |
| Singh A, Yamamoto M, Kam SHY, Ruan J, Gauvreau GM, O'Byrne PM, FitzGerald JM, Schellenberg R, Boulet L-P, Wojewodka G, Kanagaratham C, De Sanctis J, Radzioch D, Tebbutt SJ. | 2013 |
PLOS ONE |
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| Davidson WJ, Wong LE, The S, Leigh R. | 2013 |
The impact of diurnal variation on induced sputum cell counts in healthy adults |
Clinical and Translational Allergy |
| Kam SHY, Singh A, He J-Q, Ruan J, Gauvreau GM, O'Byrne PM, FitzGerald JM, Tebbutt SJ. | 2012 |
Journal of Asthma |
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| Singh A, Cohen Freue GV, Oosthuizen JL, Kam SHY, Ruan J, Takhar M, Gauvreau GM, O'Byrne PM, FitzGerald JM, Boulet L-P, Borchers CH, Tebbutt SJ. | 2012 | Plasma proteomics can discriminate isolated early from dual responses in asthmatic individuals undergoing an allergen inhalation challenge |
Proteomics ? Clinical Applications |
| Yamamoto M, Singh A, Ruan J, Gauvreau GM, O'Byrne PM, Carlsten C, FitzGerald JM, Boulet L-P, Tebbutt SJ. | 2012 |
BMC Genomics |
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| Lougheed MD, Lemière C, Ducharme FM, Lickai C, Dell SD, Rowe BH, Fitzgerald M, Leigh R, Watson W, Boulet L-P. | 2012 | Canadian Thoracic Society 2012 Guideline Update: Diagnosis and Management of Asthma in Preschoolers, Children and Adults: Executive Summary |
Canadian Respiratory Journal |
| Davenport MH, Beaudin AE, Brown AD, Leigh R, Poulin MJ. | 2012 |
Respiratory Physiology & Neurobiology |
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| Fitzgerald M. | 2012 |
Evidence-Based Medicine for Primary Care and Internal Medicine |
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| Peters GE, Davis BE, Cockcroft DW. | 2011 |
Annals of Allergy, Asthma & Immunology |
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| Kelly MM, King EM, Rider CF, Gwozd C, Holden NS, Eddleston J, Zuraw B, Leigh R, O'Byrne PM, Newton R. | 2011 |
British Journal of Pharmacology |
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| O'Byrne PM, Gauvreau GM, Murphy DM | 2009 |
Efficacy of leukotriene receptor antagonists and synthesis inhibitors in asthma |
Journal of Allergy and Clinical Immunology |