BSc, MSc, PhD
Professor, Division of Respirology, Department of Medicine, McMaster University
Dr. Gauvreau completed her BSc (Biological Science) and MSc (Clinical Studies) at the University of Guelph, PhD (Medical Science) at McMaster University, and Postdoctoral Fellowship (Clinical Immunology) at Johns Hopkins University.
Her research interests include studying the mechanisms of allergic inflammation, and identification of novel therapeutic targets for treatment of allergic disease.
Her lab, the Cardiorespiratory Research Laboratory in the Faculty of Health Sciences at McMaster University, specializes in measurements of sputum-derived cells from patients asthma. Her work using human models of disease is uncovering the impact of airway inflammation on lung function using targeted inhibition to block key cellular pathways required for developing allergen-induced airway responses.
Gauvreau GM, O'Byrne PM, Boulet L-P, Wang D, Cockcroft DW, Bigler J, Fitzgerald JM, Boedigheimer M, Davis BE, Dias C, Gorski K, Smith L, Bautista E, Comeau MR, Leigh R, Parnes JR. Effects of an anti-TSLP antibody on allergen-induced asthmatic responses. N Engl J Med. 2014 May 29;370(22):2102-10.
Gauvreau GM, Watson RM, and O’Byrne PM. Protective effects of inhaled PGE2 on allergen-induced airway responses and airway inflammation. Am J Respir Crit Care Med 1999; 159:31-36.
Gauvreau GM, Boulet LP, Cockcroft DW, Fitzgerald JM, Carlsten C, Davis BE, Deschesnes F, Duong M, Durn BL, Howie KJ, Hui L, Kasaian MT, Killian KJ, Strinich TX, Watson RM, Y N, Zhou S, Raible D, O'Byrne PM. The effects of IL-13 blockade on allergen-induced airway responses in mild atopic asthma. Am J Respir Crit Care Med. 2011;183(8):1007-14.
Gauvreau GM, Harris JM, Boulet LP, Scheerens H, Fitzgerald JM, Putnam WS, Cockcroft DW, Davis BE, Leigh R, Zheng Y, Dahlén B, Wang Y, Maciuca R, Mayers I, Liao XC, Wu LC, Matthews JG, O'Byrne PM. Targeting membrane-expressed IgE B cell receptor with an antibody to the M1 prime epitope reduces IgE production. Sci Transl Med. 2014 Jul 2;6(243):243ra85
Hallstrand TS, Leuppi JD, Joos G, Hall GL, Carlsen KH, Kaminsky DA, Coates AL, Cockcroft DW, Culver BH, Diamant Z, Gauvreau GM, Horvath I, de Jongh FHC, Laube BL, Sterk PJ, Wanger J; American Thoracic Society (ATS)/European Respiratory Society (ERS) Bronchoprovocation Testing Task Force. ERS technical standard on bronchial challenge testing: pathophysiology and methodology of indirect airway challenge testing. Eur Respir J. 2018 Nov 15;52(5). pii: 1801033. doi: 10.1183/13993003.01033-2018.
Gauvreau GM, Arm JP, Boulet LP, Leigh R, Cockcroft DW, Davis BE, Mayers I, FitzGerald JM, Dahlen B, Killian KJ, Laviolette M, Carlsten C, Lazarinis N, Watson RM, Milot J, Swystun V, Bowen M, Hui L, Lantz AS, Meiser K, Maahs S, Lowe PJ, Skerjanec A, Drollmann A, O'Byrne PM. Efficacy and safety of multiple doses of QGE031 (ligelizumab) versus omalizumab and placebo in inhibiting allergen-induced early asthmatic responses. J Allergy Clin Immunol. 2016 Oct;138(4):1051-59.
Oliveria JP, El-Gammal AI, Yee M, Obminski CD, Scime TX, Watson RM, Howie K, O'Byrne PM, Sehmi R,Gauvreau GM. Changes in regulatory B-cell levels in bone marrow, blood, and sputum of patients with asthma following inhaled allergen challenge. J Allergy Clin Immunol. 2018 Apr;141(4):1495-1498.
Salter BM, Nusca G, Tworek D, Oliveria JP, Smith SG, Watson RM, Scime T, Obminski C, Sehmi R, Gauvreau GM. Expression of activation markers in circulating basophils and the relationship to allergen-induced bronchoconstriction in subjects with mild allergic asthma. J Allergy Clin Immunol. 2016 Mar;137(3):936-938.
Salter BM, Oliveria JP, Nusca G, Smith SG, Watson RM, Comeau M, Sehmi R, Gauvreau GM. Thymic stromal lymphopoietin activation of basophils in patients with allergic asthma is IL-3 dependent. J Allergy Clin Immunol. 2015 Dec;136(6):1636-44.
Gauvreau GM, Boulet LP, Leigh R, Cockcroft DW, Killian KJ, Davis BE, Deschesnes F, Watson RM, Swystun V, Mårdh CK, Wessman P, Jorup C, Aurivillius M, O'Byrne PM. A Nonsteroidal Glucocorticoid Receptor Agonist Inhibits Allergen-induced Late Asthmatic Responses. Am J Respir Crit Care Med. 2015 Jan 15;191(2):161-7.
Gauvreau GM, Plitt JM, Baatjes AJ, MacGlashan DM. Expression of functional cysteinyl leukotriene receptors by human basophils. J Allergy Clin Immunology 2005; 116:80-7.
El-Gammal A, Oliveria JP, Howie K, Watson R, Mitchell P, Chen R, Baatjes A, Smith S, Al-Sajee D, Hawke TJ, Killian KJ, Gauvreau GM, O'Byrne PM. Allergen-induced Changes in Bone Marrow and Airway Dendritic Cells in Asthmatic Subjects. Am J Respir Crit Care Med. 2016 Jul 15;194(2):169-77.
Al-Sajee D, Sehmi R, Hawke TJ, El-Gammal A, Howie KJ, Watson RM, Londei M, Gauvreau GM, O'Byrne PM. The expression of IL-33 and TSLP and their receptors in asthmatic airways following inhaled allergen challenge. Am J Respir Crit Care Med. 2018; 198(6):805-807.
Gauvreau GM, El-Gammal AI, O'Byrne PM. Allergen-induced airway responses. Eur Respir J. 2015 Sep;46(3):819-31.
Gauvreau GM, Boulet LP, FitzGerald JM, Cockcroft DW, Davis BE, Leigh R, Tanaka M, Fourre JA, Tanaka M, Nabata T, O'Byrne PM. A dual CysLT1/2 antagonist attenuates allergen-induced airway responses in subjects with mild allergic asthma. Allergy. 2016 Dec;71(12):1721-1727.
All CIC publications featuring Dr. Gauvreau as a co-author are listed below.
| Author(s) | Year | Title | Journal |
|---|---|---|---|
| Gauvreau GM, FitzGerald JM, Boulet L-P, Watson R, Hui L, Villeneuve H, Scime T, Schlatman A, Obminski C, Kum J, Boehme S, Ly TW, Bacon K, O'Byrne PM | 2018 | The Effects of a CCR3 Inhibitor, AXP1275, on Allergen-Induced Airway Responses in Adults with Mild-to Moderate Atopic Asthma | Clinical & Experimental Allergy |
| Singh A, Shannon CP, Kim YW, Yang CX, Balshaw R, Cohen Freue GV, Gauvreau GM, FitzGerald JM, Boulet L-P, O'Byrne PM, Tebbutt SJ | 2018 | Novel blood-based transcriptional biomarker panels predict the late phase asthmatic response | American Journal of Respiratory and Critical Care Medicine |
| Tang W, Smith SG, Du W, Gugilla A, Du J, Oliveria JP, Howie K, Salter BM, Gauvreau GM, O'Byrne PM, Sehmi R | 2018 | Interleukin-25 and eosinophils progenitor cell mobilization in allergic asthma | Clinical Translational Allergy |
| Al-Sajee D, Oliveria JP, Sehmi R, Gauvreau GM | 2018 | Antialarmins for treatment of asthma: future perspectives | Current Opinion in Pulmonary Medicine |
| Revez JA, Killian KJ, O'Byrne PM, Boulet LP, Upham JW, Gauvreau GM, Ferreira MAR | 2018 | Sputum cytology during late-phase responses to inhalation challenge with different allergens | Allergy |
| Salter BMA, Smith SG, Mukherjee M, Plante S, Krisna S, Nusca G, Oliveria JP, Irshad A, Gauvreau GM, Chakir J, Nair P, Sehmi R | 2018 | Human Bronchial Epithelial Cell-derived Factors from Severe Asthmatic Subjects Stimulate Eosinophil Differentiation | American Journal of Respiratory and Critical Care Medicine |
| Nolin JD, Lai Y, Ogden HL, Manicone AM, Murphy RC, An D, Frevert CW, Ghomashchi F, Naika GS, Gelb MH, Gauvreau GM, Piliponsky AM, Altemeier WA, Hallstrand TS | 2017 | Secreted PLA2 group X orchestrates innate and adaptive immune responses to inhaled allergen | JCI Insight |
| Oliveria JP, Salter BM, MacLean J, Kotwal S, Smith A, Harris JM, Scheerens H, Sehmi R, Gauvreau GM | 2017 | Allergic asthmatics with allergy have elevated levels of IgE+ B cells in the airways | The Journal of Allergy and Clinical Immunology |
| Oliveria JP, Salter BM, MacLean J, Kotwal S, Smith A, Harris JM, Scheerens H, Sehmi R, Gauvreau GM | 2017 | Increased IgE+ B cells in sputum, but not blood, bone marrow or tonsils after inhaled allergen challenge in asthmatic subjects | American Journal of Respiratory and Critical Care Medicine |
| Chen R, Smith SG, Salter B, El-Gammal A, Oliviria JP, Obminski C, Watson R, O'Byrne PM, Gauvreau GM, Sehmi R. | 2017 | Allergen-induced Increases in Sputum Levels of Group 2 Innate Lymphoid Cells in Subjects with Asthma | American Journal of Respiratory and Critical Care Medicine |
| Coates AL, Wanger J, Cockcroft DW, Culver BH, Carlsen K-H, Diamant Z, Enright P, Gauvreau G, Hall GL, Hallstrand TS, Horvath I, deJongh FHC, Joos G, Kaminsky DA, Laube BL, Leuppi JD, Sterk PJ | 2017 | ERS technical standard on bronchial challenge testing: general considerations and performance of methacholine challenge tests | European Respiratory Journal |
| Blais C, Cockcroft DW, Veilleux J, Boulay ME, Boulet L-P, Gauvreau GM, Scime TX, Watson RM, O’Byrne PM, Davis BE | 2017 | Methacholine challenge: comparison of airway responsiveness produced by a vibrating mesh nebulizer versus a jet nebulizer | Journal of Aerosol Medicine and Pulmonary Drug Delivery |
| Gauvreau GM, Boulet LP, Leigh R, Cockcroft DW, Davis BE, Mayers I et al. | 2016 |
Journal of Allergy and Clinical Immunology |
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| Mitchell PD, Salter BM, Oliveria JP, El-Gammal A, Tworek D, Smith SG, Sehmi R, Gauvreau GM, Butler M, O'Byrne PM | 2016 |
Clinical and Experimental Allergy |
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| Tang W, Smith SG, Salter B, Oliveria JP, Mitchell P, Nusca GM, Howie K, Gauvreau GM, O'Byrne PM, Sehmi R | 2016 |
International Archives of Allergy and Immunology |
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| Todd CM, Salter BM, Murphy DM, Watson RM, Howie KJ, Milot J, Sadeh J, Boulet LP, O'Byrne PM, Gauvreau GM | 2016 |
The effects of a CXCR1/CXCR2 antagonist on neutrophil migration in mild atopic asthmatic subjects |
Pulmonary Pharmacology and Therapeutics |
| Salter BM, Manzoor F, Beaudin S, Kjarsgaard M, Nair P, Gauvreau GM, Sehmi R | 2016 |
Dysregulation of Vascular Endothelial Progenitor Cells Lung-Homing in Subjects with COPD |
Canadian Respiratory Journal |
| Gauvreau GM, Boulet LP, FitzGerald JM, Cockcroft DW, Davis BE, Leigh R, Tanaka M, Fourre JA, Tanaka M, Nabata T, O'Byrne PM | 2016 |
Allergy |
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| El-Gammal A, Oliveria JP, Howie K, Watson R, Mitchell P, Chen R, Baatjes A, Smith S, Al-Sajee D, Hawke TJ, Killian KJ, Gauvreau GM, O'Byrne PM | 2016 |
Allergen-induced Changes in Bone Marrow and Airway Dendritic Cells in Subjects with Asthma |
American Journal of Respiratory and Critical Care Medicine |
| Salter BM, Oliveria JP, Nusca G, Smith SG, Tworek D, Mitchell PD, Watson RM, Sehmi R, Gauvreau GM | 2016 |
IL-25 and IL-33 induce Type 2 inflammation in basophils from subjects with allergic asthma |
Respiratory Research |
| Tworek D, Smith SG, Salter BM, Baatjes AJ, Scime T, Watson R, Obminski C, Gauvreau GM, O'Byrne PM | 2016 |
IL-25 Receptor Expression on Airway Dendritic Cells after Allergen Challenge in Subjects with Asthma |
American Journal of Respiratory and Critical Care Medicine |
| Salter BM, Nusca G, Tworek D, Oliveria JP, Smith SG, Watson RM, Scime T, Obminski C, Sehmi R, Gauvreau GM | 2016 | Expression of activation markers in circulating basophils and the relationship to allergen-induced bronchoconstriction |
Journal of Allergy and Clinical Immunology |
| Smith SG, Chen R, Kjarsgaard M, Huang C, Oliveria JP, O'Byrne P, Gauvreau G, Boulet L-P, Lemiere C, Martin JG, Nair P, Sehmi R. | 2015 |
Journal of Allergy & Clinical Immunology |
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| Boulet LP, Gauvreau GM, Cockcroft DW, Davis B, Vachon L, Cormier Y, O'Byrne PM | 2015 |
Canadian Respiratory Journal |
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| Boulet LP, Gauvreau G, Boulay ME, O'Byrne P, Cockcroft DW | 2015 |
Allergen-induced early and late asthmatic responses to inhaled seasonal and perennial allergens |
Clinical & Experimental Allergy |
| Gauvreau GM, Boulet LP, Leigh R, Cockcroft DW, Killian KJ, Davis BE, Deschesnes F, Watson RM, Swystun V, Mårdh CK, Wessman P, Jorup C, Aurivillius M, O'Byrne PM | 2015 |
A nonsteroidal glucocorticoid receptor agonist inhibits allergen-induced late asthmatic responses |
American Journal of Respiratory and Critical Care Medicine |
| Janssen LJ, Gauvreau GM, Killian KJ, O'Byrne PM | 2015 |
The Effects of Repeated Bronchoprovocation on FEV1 in Subjects with Asthma |
Annals of the American Thoracic Society |
| Baatjes AJ, Smith SG, Dua B, Watson R, Gauvreau GM, O'Byrne PM | 2015 |
Allergy |
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| Salter BM, Oliveria JP, Nusca G, Smith SG, Watson RM, Comeau M, Sehmi R, Gauvreau GM | 2015 |
Journal of Allergy and Clinical Immunology |
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| El-Gammal AI, Killian KJ, Scime TX, Beaudin S, Schlatman A, Cockcroft DW, Gauvreau GM | 2015 |
Annals of the American Thoracic Society |
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| Watson BM, Oliveria JP, Nusca GM, Smith SG, Beaudin S, Dua B, Watson RM, Assayag EI, Cormier YF, Sehmi R, Gauvreau GM | 2015 |
Inhibition of allergen-induced basophil activation by ASM-024, a nicotinic receptor ligand |
International Archives of Allergy and Immunology |
| Smith SG, Gugilla A, Mukherjee M, Merim K, Irshad A, Tang W, Kinoshita T, Watson B, Oliveria JP, Comeau M, O'Byrne PM, Gauvreau GM, Sehmi R | 2015 | Thymic stromal lymphopoietin and IL-33 modulate migration of hematopoietic progenitor cells in patients with allergic asthma |
Journal of Allergy and Clinical Immunology |
| Gauvreau GM, Harris JM, Boulet LP, Sheerens H, FitzGerald JM, Putnam WS, Cockcroft DW, Davis BE, Leigh R, Zheng Y, Dahlén B, Wang Y, Maciuca R, Mayers I, Liao XC, Wu LC, Matthews JG, O'Byrne PM. | 2014 |
Science Translational Medicine |
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| Gauvreau GM, O'Byrne PM, Boulet L-P, Wang Y, Cockcroft DW, Bigler J, FitzGerald JM, Boedigheimer M, Davis BE, Dias C, Gorski KS, Smith L, Bautista E, Comeau MR, Leigh R, Parnes JR. | 2014 |
Effects of an Anti-TSLP Antibody on Allergen-Induced Asthmatic Responses |
The New England Journal of Medicine |
| Gauvreau GM, Boulet L-P, Cockcroft DW, FitzGerald JM, Mayers I, Carlsten C, Laviolette M, Killian KJ, Davis BE, Larché M , Kipling C , Dua B , Mosesova S , Putnam W , Zheng Y, Scheerens H, McClintock D , Matthews J, O'Byrne PM | 2014 |
OX40L blockade on allergen-induced airway responses in subjects with mild asthma |
Clinical Experimental Allergy |
| Singh A, Yamamoto M, Kam SHY, Ruan J, Gauvreau GM, O'Byrne PM, FitzGerald JM, Schellenberg R, Boulet L-P, Wojewodka G, Kanagaratham C, De Sanctis J, Radzioch D, Tebbutt SJ. | 2013 |
PLOS ONE |
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| Kam SHY, Singh A, He J-Q, Ruan J, Gauvreau GM, O'Byrne PM, FitzGerald JM, Tebbutt SJ. | 2012 |
Journal of Asthma |
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| Singh A, Cohen Freue GV, Oosthuizen JL, Kam SHY, Ruan J, Takhar M, Gauvreau GM, O'Byrne PM, FitzGerald JM, Boulet L-P, Borchers CH, Tebbutt SJ. | 2012 | Plasma proteomics can discriminate isolated early from dual responses in asthmatic individuals undergoing an allergen inhalation challenge |
Proteomics ? Clinical Applications |
| Yamamoto M, Singh A, Ruan J, Gauvreau GM, O'Byrne PM, Carlsten C, FitzGerald JM, Boulet L-P, Tebbutt SJ. | 2012 |
BMC Genomics |
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| Gauvreau GM, Boulet LP, Cockcroft DW, Fitzgerald JM, Carlsten C, Davis BE, Deschesnes F, Duong M, Durn BL, Howie KJ, Hui L, Kasaian MT, Killian KJ, Strinich TX, Watson RM, Y N, Zhou S, Raible D, O'Byrne PM. | 2011 |
The effects of IL-13 blockade on allergen-induced airway responses in mild atopic asthma |
American Journal of Respiratory and Critical Care Medicine |
| Kelly MM, O'Connor TM, Leigh R, Otis J, Gwozd C, Gauvreau GM, Gauldie J, O'Byrne PM. | 2010 | Effects of budesonide and formoterol on allergen-induced airway responses, inflammation, and airway remodeling in asthma |
Journal of Allergy and Clinical Immunology |
| Davis BE, Illamperuma C, Gauvreau GM, Watson RM, O'Byrne PM, Deschesnes F, Boulet LP, Cockcroft DW. | 2009 |
Single dose desloratadine and montelukast and allergen-induced late airway responses |
European Respiratory Journal |
| Boulet L-P, Lemière C, Gauvreau GM, Olivenstein R, Lougheed D, Paradis B, O’Byrne P, Pageau R, Renzi PM. | 2009 |
Safety, pharmacodynamics and pharmacokinetics of TPI 1020 in smokers with asthma |
Respiratory Medicine |
| O'Byrne PM, Gauvreau G. | 2009 |
The Lancet |
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| O'Byrne PM, Gauvreau GM, Murphy DM | 2009 |
Efficacy of leukotriene receptor antagonists and synthesis inhibitors in asthma |
Journal of Allergy and Clinical Immunology |
| O'Byrne PM, van der Linde J, Cockcroft DW, Gauvreau GM, Brannan JD, FitzGerald JM, Watson RM, Milot J, Davis B, O?Connor M, Hart L, Korducki L, Hamilton J. | 2009 | Prolonged bronchoprotection against inhaled methacholine by inhaled BI 1744, a long-acting β2-agonist, in mild asthmatics |
Journal of Allergy and Clinical Immunology |
| Gauvreau GM, Boulet L-P, Cockcroft DW, Baatjes A, Cote J, Deschesnes F, Davis B, Strinich T, Howie K, Duong M, Watson RM, Renzi PM, O'Byrne, PM. | 2008 | Antisense therapy against CCR3 and the common beta chain attenuates allergen-induced eosinophilic responses |
American Journal of Respiratory and Critical Care Medicine |
| Duong M, Cockcroft D, Boulet L-P, Ahmed T, Iverson H, Atkinson D, Stahl E, Watson R, Davis B, Milo J, Gauvreau G, O'Byrne P. | 2008 |
Allergy |