Gail Gauvreau

BSc, MSc, PhD

Professor, Division of Respirology, Department of Medicine, McMaster University

Dr. Gauvreau completed her BSc (Biological Science) and MSc (Clinical Studies) at the University of Guelph, PhD (Medical Science) at McMaster University, and Postdoctoral Fellowship (Clinical Immunology) at Johns Hopkins University.

Her research interests include studying the mechanisms of allergic inflammation, and identification of novel therapeutic targets for treatment of allergic disease.

Her lab, the Cardiorespiratory Research Laboratory in the Faculty of Health Sciences at McMaster University, specializes in measurements of sputum-derived cells from patients asthma. Her work using human models of disease is uncovering the impact of airway inflammation on lung function using targeted inhibition to block key cellular pathways required for developing allergen-induced airway responses.


Gauvreau GM, O'Byrne PM, Boulet L-P, Wang D, Cockcroft DW, Bigler J, Fitzgerald JM, Boedigheimer M, Davis BE, Dias C, Gorski K, Smith L, Bautista E, Comeau MR, Leigh R, Parnes JR. Effects of an anti-TSLP antibody on allergen-induced asthmatic responses. N Engl J Med. 2014 May 29;370(22):2102-10.

Gauvreau GM, Watson RM, and O’Byrne PM. Protective effects of inhaled PGE2 on allergen-induced airway responses and airway inflammation. Am J Respir Crit Care Med 1999; 159:31-36.

Gauvreau GM, Boulet LP, Cockcroft DW, Fitzgerald JM, Carlsten C, Davis BE, Deschesnes F, Duong M, Durn BL, Howie KJ, Hui L, Kasaian MT, Killian KJ, Strinich TX, Watson RM, Y N, Zhou S, Raible D, O'Byrne PM. The effects of IL-13 blockade on allergen-induced airway responses in mild atopic asthma. Am J Respir Crit Care Med. 2011;183(8):1007-14.

Gauvreau GM, Harris JM, Boulet LP, Scheerens H, Fitzgerald JM, Putnam WS, Cockcroft DW, Davis BE, Leigh R, Zheng Y, Dahlén B, Wang Y, Maciuca R, Mayers I, Liao XC, Wu LC, Matthews JG, O'Byrne PM. Targeting membrane-expressed IgE B cell receptor with an antibody to the M1 prime epitope reduces IgE production. Sci Transl Med. 2014 Jul 2;6(243):243ra85

Hallstrand TS, Leuppi JD, Joos G, Hall GL, Carlsen KH, Kaminsky DA, Coates AL, Cockcroft DW, Culver BH, Diamant Z, Gauvreau GM, Horvath I, de Jongh FHC, Laube BL, Sterk PJ, Wanger J; American Thoracic Society (ATS)/European Respiratory Society (ERS) Bronchoprovocation Testing Task Force. ERS technical standard on bronchial challenge testing: pathophysiology and methodology of indirect airway challenge testing. Eur Respir J. 2018 Nov 15;52(5). pii: 1801033. doi: 10.1183/13993003.01033-2018.

Gauvreau GM, Arm JP, Boulet LP, Leigh R, Cockcroft DW, Davis BE, Mayers I, FitzGerald JM, Dahlen B, Killian KJ, Laviolette M, Carlsten C, Lazarinis N, Watson RM, Milot J, Swystun V, Bowen M, Hui L, Lantz AS, Meiser K, Maahs S, Lowe PJ, Skerjanec A, Drollmann A, O'Byrne PM. Efficacy and safety of multiple doses of QGE031 (ligelizumab) versus omalizumab and placebo in inhibiting allergen-induced early asthmatic responses. J Allergy Clin Immunol. 2016 Oct;138(4):1051-59.

Oliveria JP, El-Gammal AI, Yee M, Obminski CD, Scime TX, Watson RM, Howie K, O'Byrne PM, Sehmi R,Gauvreau GM. Changes in regulatory B-cell levels in bone marrow, blood, and sputum of patients with asthma following inhaled allergen challenge. J Allergy Clin Immunol. 2018 Apr;141(4):1495-1498.

Salter BM, Nusca G, Tworek D, Oliveria JP, Smith SG, Watson RM, Scime T, Obminski C, Sehmi R, Gauvreau GM. Expression of activation markers in circulating basophils and the relationship to allergen-induced bronchoconstriction in subjects with mild allergic asthma. J Allergy Clin Immunol. 2016 Mar;137(3):936-938.

Salter BM, Oliveria JP, Nusca G, Smith SG, Watson RM, Comeau M, Sehmi R, Gauvreau GM. Thymic stromal lymphopoietin activation of basophils in patients with allergic asthma is IL-3 dependent. J Allergy Clin Immunol. 2015 Dec;136(6):1636-44.

Gauvreau GM, Boulet LP, Leigh R, Cockcroft DW, Killian KJ, Davis BE, Deschesnes F, Watson RM, Swystun V, Mårdh CK, Wessman P, Jorup C, Aurivillius M, O'Byrne PM. A Nonsteroidal Glucocorticoid Receptor Agonist Inhibits Allergen-induced Late Asthmatic Responses. Am J Respir Crit Care Med. 2015 Jan 15;191(2):161-7.

Gauvreau GM, Plitt JM, Baatjes AJ, MacGlashan DM. Expression of functional cysteinyl leukotriene receptors by human basophils. J Allergy Clin Immunology 2005; 116:80-7.

El-Gammal A, Oliveria JP, Howie K, Watson R, Mitchell P, Chen R, Baatjes A, Smith S, Al-Sajee D, Hawke TJ, Killian KJ, Gauvreau GM, O'Byrne PM. Allergen-induced Changes in Bone Marrow and Airway Dendritic Cells in Asthmatic Subjects. Am J Respir Crit Care Med. 2016 Jul 15;194(2):169-77.

Al-Sajee D, Sehmi R, Hawke TJ, El-Gammal A, Howie KJ, Watson RM, Londei M, Gauvreau GM, O'Byrne PM. The expression of IL-33 and TSLP and their receptors in asthmatic airways following inhaled allergen challenge. Am J Respir Crit Care Med. 2018; 198(6):805-807.

Gauvreau GM, El-Gammal AI, O'Byrne PM. Allergen-induced airway responses. Eur Respir J. 2015 Sep;46(3):819-31.

Gauvreau GM, Boulet LP, FitzGerald JM, Cockcroft DW, Davis BE, Leigh R, Tanaka M, Fourre JA, Tanaka M, Nabata T, O'Byrne PM. A dual CysLT1/2 antagonist attenuates allergen-induced airway responses in subjects with mild allergic asthma. Allergy. 2016 Dec;71(12):1721-1727.


All CIC publications featuring Dr. Gauvreau as a co-author are listed below.

Total Records Found: 48, showing 100 per page
Author(s)YearTitleJournal
Gauvreau GM, FitzGerald JM, Boulet L-P, Watson R, Hui L, Villeneuve H, Scime T, Schlatman A, Obminski C, Kum J, Boehme S, Ly TW, Bacon K, O'Byrne PM 2018 The Effects of a CCR3 Inhibitor, AXP1275, on Allergen-Induced Airway Responses in Adults with Mild-to Moderate Atopic Asthma Clinical & Experimental Allergy
Singh A, Shannon CP, Kim YW, Yang CX, Balshaw R, Cohen Freue GV, Gauvreau GM, FitzGerald JM, Boulet L-P, O'Byrne PM, Tebbutt SJ 2018 Novel blood-based transcriptional biomarker panels predict the late phase asthmatic response American Journal of Respiratory and Critical Care Medicine
Tang W, Smith SG, Du W, Gugilla A, Du J, Oliveria JP, Howie K, Salter BM, Gauvreau GM, O'Byrne PM, Sehmi R 2018 Interleukin-25 and eosinophils progenitor cell mobilization in allergic asthma Clinical Translational Allergy
Al-Sajee D, Oliveria JP, Sehmi R, Gauvreau GM 2018 Antialarmins for treatment of asthma: future perspectives Current Opinion in Pulmonary Medicine
Revez JA, Killian KJ, O'Byrne PM, Boulet LP, Upham JW, Gauvreau GM, Ferreira MAR 2018 Sputum cytology during late-phase responses to inhalation challenge with different allergens Allergy
Salter BMA, Smith SG, Mukherjee M, Plante S, Krisna S, Nusca G, Oliveria JP, Irshad A, Gauvreau GM, Chakir J, Nair P, Sehmi R 2018 Human Bronchial Epithelial Cell-derived Factors from Severe Asthmatic Subjects Stimulate Eosinophil Differentiation American Journal of Respiratory and Critical Care Medicine
Nolin JD, Lai Y, Ogden HL, Manicone AM, Murphy RC, An D, Frevert CW, Ghomashchi F, Naika GS, Gelb MH, Gauvreau GM, Piliponsky AM, Altemeier WA, Hallstrand TS 2017 Secreted PLA2 group X orchestrates innate and adaptive immune responses to inhaled allergen JCI Insight
Oliveria JP, Salter BM, MacLean J, Kotwal S, Smith A, Harris JM, Scheerens H, Sehmi R, Gauvreau GM 2017 Allergic asthmatics with allergy have elevated levels of IgE+ B cells in the airways The Journal of Allergy and Clinical Immunology
Oliveria JP, Salter BM, MacLean J, Kotwal S, Smith A, Harris JM, Scheerens H, Sehmi R, Gauvreau GM 2017 Increased IgE+ B cells in sputum, but not blood, bone marrow or tonsils after inhaled allergen challenge in asthmatic subjects American Journal of Respiratory and Critical Care Medicine
Chen R, Smith SG, Salter B, El-Gammal A, Oliviria JP, Obminski C, Watson R, O'Byrne PM, Gauvreau GM, Sehmi R. 2017 Allergen-induced Increases in Sputum Levels of Group 2 Innate Lymphoid Cells in Subjects with Asthma American Journal of Respiratory and Critical Care Medicine
Coates AL, Wanger J, Cockcroft DW, Culver BH, Carlsen K-H, Diamant Z, Enright P, Gauvreau G, Hall GL, Hallstrand TS, Horvath I, deJongh FHC, Joos G, Kaminsky DA, Laube BL, Leuppi JD, Sterk PJ 2017 ERS technical standard on bronchial challenge testing: general considerations and performance of methacholine challenge tests European Respiratory Journal
Blais C, Cockcroft DW, Veilleux J, Boulay ME, Boulet L-P, Gauvreau GM, Scime TX, Watson RM, O’Byrne PM, Davis BE 2017 Methacholine challenge: comparison of airway responsiveness produced by a vibrating mesh nebulizer versus a jet nebulizer Journal of Aerosol Medicine and Pulmonary Drug Delivery
Gauvreau GM, Boulet LP, Leigh R, Cockcroft DW, Davis BE, Mayers I et al. 2016

Efficacy and safety of multiple doses of QGE031 (ligelizumab) versus omalizumab and placebo in inhibiting allergen-induced early asthmatic responses

Journal of Allergy and Clinical Immunology

Mitchell PD, Salter BM, Oliveria JP, El-Gammal A, Tworek D, Smith SG, Sehmi R, Gauvreau GM, Butler M, O'Byrne PM 2016

Glucagon Like Peptide-1 receptor expression on human eosinophils and its regulation of eosinophil activation

Clinical and Experimental Allergy

Tang W, Smith SG, Salter B, Oliveria JP, Mitchell P, Nusca GM, Howie K, Gauvreau GM, O'Byrne PM, Sehmi R 2016

Allergen-Induced Increases in Interleukin-25 and Interleukin-25 Receptor Expression in Mature Eosinophils from Atopic Asthmatics</stron

International Archives of Allergy and Immunology

Todd CM, Salter BM, Murphy DM, Watson RM, Howie KJ, Milot J, Sadeh J, Boulet LP, O'Byrne PM, Gauvreau GM 2016

The effects of a CXCR1/CXCR2 antagonist on neutrophil migration in mild atopic asthmatic subjects

Pulmonary Pharmacology and Therapeutics

Salter BM, Manzoor F, Beaudin S, Kjarsgaard M, Nair P, Gauvreau GM, Sehmi R 2016

Dysregulation of Vascular Endothelial Progenitor Cells Lung-Homing in Subjects with COPD

Canadian Respiratory Journal

Gauvreau GM, Boulet LP, FitzGerald JM, Cockcroft DW, Davis BE, Leigh R, Tanaka M, Fourre JA, Tanaka M, Nabata T, O'Byrne PM 2016

A dual CysLT1/2 antagonist attenuates allergen-induced airway responses in subjects with mild allergic asthma

Allergy

El-Gammal A, Oliveria JP, Howie K, Watson R, Mitchell P, Chen R, Baatjes A, Smith S, Al-Sajee D, Hawke TJ, Killian KJ, Gauvreau GM, O'Byrne PM 2016

Allergen-induced Changes in Bone Marrow and Airway Dendritic Cells in Subjects with Asthma

American Journal of Respiratory and Critical Care Medicine

Salter BM, Oliveria JP, Nusca G, Smith SG, Tworek D, Mitchell PD, Watson RM, Sehmi R, Gauvreau GM 2016

IL-25 and IL-33 induce Type 2 inflammation in basophils from subjects with allergic asthma

Respiratory Research

Tworek D, Smith SG, Salter BM, Baatjes AJ, Scime T, Watson R, Obminski C, Gauvreau GM, O'Byrne PM 2016

IL-25 Receptor Expression on Airway Dendritic Cells after Allergen Challenge in Subjects with Asthma

American Journal of Respiratory and Critical Care Medicine

Salter BM, Nusca G, Tworek D, Oliveria JP, Smith SG, Watson RM, Scime T, Obminski C, Sehmi R, Gauvreau GM 2016 Expression of activation markers in circulating basophils and the relationship to allergen-induced bronchoconstriction

Journal of Allergy and Clinical Immunology

Smith SG, Chen R, Kjarsgaard M, Huang C, Oliveria JP, O'Byrne P, Gauvreau G, Boulet L-P, Lemiere C, Martin JG, Nair P, Sehmi R. 2015

Increased numbers of activated group 2 innate lymphoid cells in the airways of patients with severe asthma and persistent airway eosinophilia

Journal of Allergy & Clinical Immunology

Boulet LP, Gauvreau GM, Cockcroft DW, Davis B, Vachon L, Cormier Y, O'Byrne PM 2015

Effects of ASM-024, a modulator of acetylcholine receptor function, on airway responsiveness and allergen-induced responses in patients with mild asthma

Canadian Respiratory Journal

Boulet LP, Gauvreau G, Boulay ME, O'Byrne P, Cockcroft DW 2015

Allergen-induced early and late asthmatic responses to inhaled seasonal and perennial allergens

Clinical & Experimental Allergy

Gauvreau GM, Boulet LP, Leigh R, Cockcroft DW, Killian KJ, Davis BE, Deschesnes F, Watson RM, Swystun V, Mårdh CK, Wessman P, Jorup C, Aurivillius M, O'Byrne PM 2015

A nonsteroidal glucocorticoid receptor agonist inhibits allergen-induced late asthmatic responses

American Journal of Respiratory and Critical Care Medicine

Janssen LJ, Gauvreau GM, Killian KJ, O'Byrne PM 2015

The Effects of Repeated Bronchoprovocation on FEV1 in Subjects with Asthma

Annals of the American Thoracic Society

Baatjes AJ, Smith SG, Dua B, Watson R, Gauvreau GM, O'Byrne PM 2015

Treatment with anti-OX40L or anti-TSLP does not alter the frequency of T regulatory cells in allergic asthmatics

Allergy

Salter BM, Oliveria JP, Nusca G, Smith SG, Watson RM, Comeau M, Sehmi R, Gauvreau GM 2015

Thymic stromal lymphopoietin activation of basophils in patients with allergic asthma is IL-3 dependent

Journal of Allergy and Clinical Immunology

El-Gammal AI, Killian KJ, Scime TX, Beaudin S, Schlatman A, Cockcroft DW, Gauvreau GM 2015

Comparison of the provocative concentration of methacholine causing a 20% fall in FEV1 between the AeroEclipse II breath-actuated nebulizer and the wright nebulizer in adult subjects with Asthma

Annals of the American Thoracic Society

Watson BM, Oliveria JP, Nusca GM, Smith SG, Beaudin S, Dua B, Watson RM, Assayag EI, Cormier YF, Sehmi R, Gauvreau GM 2015

Inhibition of allergen-induced basophil activation by ASM-024, a nicotinic receptor ligand

International Archives of Allergy and Immunology

Smith SG, Gugilla A, Mukherjee M, Merim K, Irshad A, Tang W, Kinoshita T, Watson B, Oliveria JP, Comeau M, O'Byrne PM, Gauvreau GM, Sehmi R 2015 Thymic stromal lymphopoietin and IL-33 modulate migration of hematopoietic progenitor cells in patients with allergic asthma

Journal of Allergy and Clinical Immunology

Gauvreau GM, Harris JM, Boulet LP, Sheerens H, FitzGerald JM, Putnam WS, Cockcroft DW, Davis BE, Leigh R, Zheng Y, Dahlén B, Wang Y, Maciuca R, Mayers I, Liao XC, Wu LC, Matthews JG, O'Byrne PM. 2014

Targeting membrane-expressed IgE B cell receptor with an antibody to the M1 prime epitope reduces IgE production

Science Translational Medicine

Gauvreau GM, O'Byrne PM, Boulet L-P, Wang Y, Cockcroft DW, Bigler J, FitzGerald JM, Boedigheimer M, Davis BE, Dias C, Gorski KS, Smith L, Bautista E, Comeau MR, Leigh R, Parnes JR. 2014

Effects of an Anti-TSLP Antibody on Allergen-Induced Asthmatic Responses

The New England Journal of Medicine

Gauvreau GM, Boulet L-P, Cockcroft DW, FitzGerald JM, Mayers I, Carlsten C, Laviolette M, Killian KJ, Davis BE, Larché M , Kipling C , Dua B , Mosesova S , Putnam W , Zheng Y, Scheerens H, McClintock D , Matthews J, O'Byrne PM 2014

OX40L blockade on allergen-induced airway responses in subjects with mild asthma

Clinical Experimental Allergy

Singh A, Yamamoto M, Kam SHY, Ruan J, Gauvreau GM, O'Byrne PM, FitzGerald JM, Schellenberg R, Boulet L-P, Wojewodka G, Kanagaratham C, De Sanctis J, Radzioch D, Tebbutt SJ. 2013

Gene-metabolite expression in blood can discriminate allergen-induced isolated early from dual asthmatic responses

PLOS ONE

Kam SHY, Singh A, He J-Q, Ruan J, Gauvreau GM, O'Byrne PM, FitzGerald JM, Tebbutt SJ. 2012

Peripheral blood gene expression changes during allergen inhalation challenge in atopic asthmatic individuals

Journal of Asthma

Singh A, Cohen Freue GV, Oosthuizen JL, Kam SHY, Ruan J, Takhar M, Gauvreau GM, O'Byrne PM, FitzGerald JM, Boulet L-P, Borchers CH, Tebbutt SJ. 2012 Plasma proteomics can discriminate isolated early from dual responses in asthmatic individuals undergoing an allergen inhalation challenge

Proteomics ? Clinical Applications

Yamamoto M, Singh A, Ruan J, Gauvreau GM, O'Byrne PM, Carlsten C, FitzGerald JM, Boulet L-P, Tebbutt SJ. 2012

Decreased miR-192 expression in peripheral blood of asthmatic individuals undergoing an allergen inhalation challenge

BMC Genomics

Gauvreau GM, Boulet LP, Cockcroft DW, Fitzgerald JM, Carlsten C, Davis BE, Deschesnes F, Duong M, Durn BL, Howie KJ, Hui L, Kasaian MT, Killian KJ, Strinich TX, Watson RM, Y N, Zhou S, Raible D, O'Byrne PM. 2011

The effects of IL-13 blockade on allergen-induced airway responses in mild atopic asthma

American Journal of Respiratory and Critical Care Medicine

Kelly MM, O'Connor TM, Leigh R, Otis J, Gwozd C, Gauvreau GM, Gauldie J, O'Byrne PM. 2010 Effects of budesonide and formoterol on allergen-induced airway responses, inflammation, and airway remodeling in asthma

Journal of Allergy and Clinical Immunology

Davis BE, Illamperuma C, Gauvreau GM, Watson RM, O'Byrne PM, Deschesnes F, Boulet LP, Cockcroft DW. 2009

Single dose desloratadine and montelukast and allergen-induced late airway responses

European Respiratory Journal

Boulet L-P, Lemière C, Gauvreau GM, Olivenstein R, Lougheed D, Paradis B, O’Byrne P, Pageau R, Renzi PM. 2009

Safety, pharmacodynamics and pharmacokinetics of TPI 1020 in smokers with asthma

Respiratory Medicine

O'Byrne PM, Gauvreau G. 2009

Phosphodiesterase-4 inhibition in COPD

The Lancet

O'Byrne PM, Gauvreau GM, Murphy DM 2009

Efficacy of leukotriene receptor antagonists and synthesis inhibitors in asthma

Journal of Allergy and Clinical Immunology

O'Byrne PM, van der Linde J, Cockcroft DW, Gauvreau GM, Brannan JD, FitzGerald JM, Watson RM, Milot J, Davis B, O?Connor M, Hart L, Korducki L, Hamilton J. 2009 Prolonged bronchoprotection against inhaled methacholine by inhaled BI 1744, a long-acting β2-agonist, in mild asthmatics

Journal of Allergy and Clinical Immunology

Gauvreau GM, Boulet L-P, Cockcroft DW, Baatjes A, Cote J, Deschesnes F, Davis B, Strinich T, Howie K, Duong M, Watson RM, Renzi PM, O'Byrne, PM. 2008 Antisense therapy against CCR3 and the common beta chain attenuates allergen-induced eosinophilic responses

American Journal of Respiratory and Critical Care Medicine

Duong M, Cockcroft D, Boulet L-P, Ahmed T, Iverson H, Atkinson D, Stahl E, Watson R, Davis B, Milo J, Gauvreau G, O'Byrne P. 2008

The effect of IVX-0142, a heparin-derived hypersulfated disaccharide, on the allergic airway responses in asthma

Allergy

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