BSc, MD, FRCPC
Professor, Division of Respirology, Critical Care and Sleep Medicine, Department of Medicine, University of Saskatchewan
Dr. Cockcroft's research focuses on clinical investigations in asthma, primarily bronchoprovocation with methacholine and other nonallergic stimuli, and the development and use of the allergen challenge model for investigating both the pathophysiology of asthma and new drugs for asthma.
Dr. Cockcroft is a respirologist and world-renowned asthma researcher. His research advances in asthma diagnosis and care have impacted clinical practice for this disease in Canada, and around the world. He is a Fellow of the American Academy of Asthma, Allergy and Immunology, the American College of Allergy, Asthma and Immunology, and the American College of Chest Physicians. He is a Past-President of the Canadian Thoracic Society and a former Head of the University of Saskatchewan's Division of Respirology, Critical Care and Sleep Medicine.
Dr. Cockcroft has co-authored in excess of 100 book chapters/review articles, more than 280 peer-reviewed research papers, and has presented approximately 300 invited lectures at regional, national and international meetings.
Cockcroft DW, Killian DN, Mellon JJA, Hargreave FE. Bronchial reactivity to inhaled histamine: a method and clinical survey. Clinical and Experimental Allergy. 1977 May;7(3):235-243.
Cockcroft DW, Ruffin RE, Dolovich J, Hargreave FE. Allergen-induced increase in nonallergic bronchial reactivity. Clinical Allergy. 1977 Nov;7(6):503-513.
Cockcroft DW, Murdock KY, Kirby J, Hargreave FE. Prediction of airway responsiveness to allergen from skin sensitivity to allergen and airway responsiveness to histamine. American Review of Respiratory Disease. 1987 Jan;135(1):264-267.
Cockcroft DW, Murdock KY. Comparative effects of inhaled salbutamol, sodium cromoglycate, and beclomethasone dipropionate on allergen induced early asthmatic responses, late asthmatic responses and increased bronchial responsiveness to histamine. Journal of Allergy and Clinical Immunology. 1987 Apr;79(5):734-740.
Spitzer WO, Suissa S, Ernst P, Horwitz RI, Habbick B, Cockcroft D, Boivin J-F, McNutt M, Buist AS, Rebuck AS. The use of beta-agonist and the risk of death and near death from asthma. New England Journal of Medicine. 1992 Feb;326(8):501-506.Cockcroft DW, McParland CP, O'Byrne PM, Manning P, Friend JL, Rutherford BC, Swystun VA. Beclomethasone given after the early asthmatic response inhibits the late response and the increased methacholine responsiveness and cromolyn does not. Journal of Allergy and Clinical Immunology. 1993 Jun;91(6):1163-1168.
Cockcroft DW, McParland CM, Britto SA, Swystun VA, Rutherford BC. Regular inhaled salbutamol and airway responsiveness to allergen. The Lancet. 1993 Oct;342(8875):833-837.
Suissa S, Ernst P, Boivin J-F, Horwitz RI, Habbick B, Cockcroft D, Blais L, McNutt M, Buist AS, Spitzer WO. A cohort analysis of excess mortality in asthma and the use of inhaled beta agonists. American Journal of Respiratory and Critical Care Medicine. 1994 Mar;149(3):604-610.
Bhagat R, Kalra S, Swystun VA, Cockcroft DW. Rapid onset of tolerance to the bronchoprotective effect of salmeterol. Chest. 1995 Nov;108(5):1235-1239.
Gauvreau GM, Jordana M, Watson RM, Cockcroft DW, O'Byrne PM. Effect of regular inhaled albuterol on allergen-induced late responses and sputum eosinophils in asthmatic subjects. American Journal of Respiratory and Critical Care Medicine. 1997 Dec;156(6):1738-1745.
Swystun VA, Gordon JR, Davis EE, Zhang X, Cockcroft DW. Mast cell tryptase release and asthmatic responses to allergen increase with regular use of salbutamol. Journal of Allergy and Clinical Immunology. 2000 Jul;106(1 Pt 1):57-64.
Cockcroft DW, Davis BE. The bronchoprotective effect of inhaling methacholine by using total lung capacity inspirations has a marked influence on the interpretation of the test result. Journal of Allergy and Clinical Immunology. 2006 Jun;117(6):1244-1248.
Davis BE, Illamperuma C, Gauvreau GM, Watson RM, O'Byrne PM, Deschesnes F, Boulet L-P, Cockcroft DW. Single dose desloratadine and montelukast and allergen-induced late airway responses. European Respiratory Journal. 2009 Jun;33(6):1302-1308.
Davis BE, Simonson SK, Blais CM,Cockcroft DW. Methacholine challenge testing: a novel method for measuring PD20. CHEST. 2017;152(6):1251-1256.
Cockcroft DW, Davis BE, Blais CM. Thunderstorm asthma: an allergen-induced early asthmatic response. Annals of Allergy, Asthma and Immunology. 2018;120(2):120-123.
All CIC publications featuring Dr. Cockcroft as a co-author are listed below.
| Author(s) | Year | Title | Journal |
|---|---|---|---|
| Lawson JA, Rennie DC, Cockcroft DW, Dyck R, Afanasieva A, Oluwole O, Afsana J. | 2017 | Childhood asthma, asthma severity indicators, and related conditions along an urban-rural gradient: a cross-sectional study</a | BMC Pulmonary Medicine |
| Lok SD, Davis BE, Cockcroft DW | 2017 | Prevalence of allergen sensitization in 1000 adults in Saskatchewan | Allergy, Asthma & Clinical Immunology |
| Nair P, Martin JG, Cockcroft DC, Dolovich M, Lemiere C, Boulet LP, O'Byrne PM | 2017 | Airway Hyperresponsiveness in Asthma: Measurement and Clinical Relevance | Journal of Allergy and Clinical Immunology: In Practice |
| Oluwole O, Kirychuk SP, Lawson JA, Karunanayake C, Cockcroft DW, Willson PJ, Senthilselvan A, Rennie DC. | 2017 | Indoor mold levels and current asthma among school-aged children in Saskatchewan, Canada | Indoor Air |
| Coates AL, Wanger J, Cockcroft DW, Culver BH, Carlsen K-H, Diamant Z, Enright P, Gauvreau G, Hall GL, Hallstrand TS, Horvath I, deJongh FHC, Joos G, Kaminsky DA, Laube BL, Leuppi JD, Sterk PJ | 2017 | ERS technical standard on bronchial challenge testing: general considerations and performance of methacholine challenge tests | European Respiratory Journal |
| Blais C, Cockcroft DW, Veilleux J, Boulay ME, Boulet L-P, Gauvreau GM, Scime TX, Watson RM, O’Byrne PM, Davis BE | 2017 | Methacholine challenge: comparison of airway responsiveness produced by a vibrating mesh nebulizer versus a jet nebulizer | Journal of Aerosol Medicine and Pulmonary Drug Delivery |
| Gauvreau GM, Boulet LP, Leigh R, Cockcroft DW, Davis BE, Mayers I et al. | 2016 |
Journal of Allergy and Clinical Immunology |
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| Gauvreau GM, Boulet LP, FitzGerald JM, Cockcroft DW, Davis BE, Leigh R, Tanaka M, Fourre JA, Tanaka M, Nabata T, O'Byrne PM | 2016 |
Allergy |
|
| Cockcroft DW | 2016 | Giants in allergy-immunology: Frederick E. “Freddy” Hargreave, MB ChB, MD | Annals of Allergy, Asthma & Immunology |
| Blais CM, Davis BE, Cockcroft DW. | 2016 | Duration of bronchoprotection of the long-acting muscarinic antagonists tiotropium & glycopyrronium against methacholineinduced bronchoconstriction in mild asthmatics | Respiratory Medicine |
| Boulet LP, Gauvreau GM, Cockcroft DW, Davis B, Vachon L, Cormier Y, O'Byrne PM | 2015 |
Canadian Respiratory Journal |
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| Boulet LP, Gauvreau G, Boulay ME, O'Byrne P, Cockcroft DW | 2015 |
Allergen-induced early and late asthmatic responses to inhaled seasonal and perennial allergens |
Clinical & Experimental Allergy |
| Gauvreau GM, Boulet LP, Leigh R, Cockcroft DW, Killian KJ, Davis BE, Deschesnes F, Watson RM, Swystun V, Mårdh CK, Wessman P, Jorup C, Aurivillius M, O'Byrne PM | 2015 |
A nonsteroidal glucocorticoid receptor agonist inhibits allergen-induced late asthmatic responses |
American Journal of Respiratory and Critical Care Medicine |
| Olfert J, Gjevre J,Cockcroft D. | 2015 |
Journal of Allergy and Clinical Immunology: In Practice |
|
| Davis BE, Amakye DO, Cockcroft DW | 2015 |
Airway responsiveness to mannitol 24 hours after 7b allergen challenge in atopic asthmatics |
Allergy |
| El-Gammal AI, Killian KJ, Scime TX, Beaudin S, Schlatman A, Cockcroft DW, Gauvreau GM | 2015 |
Annals of the American Thoracic Society |
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| Gauvreau GM, Harris JM, Boulet LP, Sheerens H, FitzGerald JM, Putnam WS, Cockcroft DW, Davis BE, Leigh R, Zheng Y, Dahlén B, Wang Y, Maciuca R, Mayers I, Liao XC, Wu LC, Matthews JG, O'Byrne PM. | 2014 |
Science Translational Medicine |
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| Gauvreau GM, O'Byrne PM, Boulet L-P, Wang Y, Cockcroft DW, Bigler J, FitzGerald JM, Boedigheimer M, Davis BE, Dias C, Gorski KS, Smith L, Bautista E, Comeau MR, Leigh R, Parnes JR. | 2014 |
Effects of an Anti-TSLP Antibody on Allergen-Induced Asthmatic Responses |
The New England Journal of Medicine |
| Gauvreau GM, Boulet L-P, Cockcroft DW, FitzGerald JM, Mayers I, Carlsten C, Laviolette M, Killian KJ, Davis BE, Larché M , Kipling C , Dua B , Mosesova S , Putnam W , Zheng Y, Scheerens H, McClintock D , Matthews J, O'Byrne PM | 2014 |
OX40L blockade on allergen-induced airway responses in subjects with mild asthma |
Clinical Experimental Allergy |
| Nataraj RTY,Cockcroft DW, Fladeland DA. | 2014 |
Journal of Allergy and Clinical Immunology: In Practice |
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| Davis BE, Stewart SL, Martin AL, Cockcroft DW. | 2014 | Low levels of fractional exhaled nitric oxide and deep inhalation bronchoprotection are associated with mannitol non-responsiveness in asthma |
Respiratory Medicine |
| Gauvreau GM, Boulet LP, Cockcroft DW, Fitzgerald JM, Carlsten C, Davis BE, Deschesnes F, Duong M, Durn BL, Howie KJ, Hui L, Kasaian MT, Killian KJ, Strinich TX, Watson RM, Y N, Zhou S, Raible D, O'Byrne PM. | 2011 |
The effects of IL-13 blockade on allergen-induced airway responses in mild atopic asthma |
American Journal of Respiratory and Critical Care Medicine |
| Peters GE, Davis BE, Cockcroft DW. | 2011 |
Annals of Allergy, Asthma & Immunology |
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| Li X, Yang A, Huang H, Zhang X, Town J, Davis B, Cockcroft DW, Gordon JR. | 2010 |
American Journal of Respiratory Cell and Molecular Biology |
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| Gaurvreau GM, Boulet LP, Cockcroft DW, FitzGerald JM, Carlsten C, Davis BE, Deschesnes F, Duong M, Durn BL, Howie KJ, Hui L, Kasaian MT, Killian KJ, Strinich TX, Watson RM, Zhou S, Raible D, O'Byrne PM. | 2010 |
Effects of interleukin-13 blockade on allergen-induced airway responses in mild atopic asthma |
American Journal of Respiratory and Critical Care Medicine |
| Davis BE, Illamperuma C, Gauvreau GM, Watson RM, O'Byrne PM, Deschesnes F, Boulet LP, Cockcroft DW. | 2009 |
Single dose desloratadine and montelukast and allergen-induced late airway responses |
European Respiratory Journal |
| O'Byrne PM, van der Linde J, Cockcroft DW, Gauvreau GM, Brannan JD, FitzGerald JM, Watson RM, Milot J, Davis B, O?Connor M, Hart L, Korducki L, Hamilton J. | 2009 | Prolonged bronchoprotection against inhaled methacholine by inhaled BI 1744, a long-acting β2-agonist, in mild asthmatics |
Journal of Allergy and Clinical Immunology |
| Gauvreau GM, Boulet L-P, Cockcroft DW, Baatjes A, Cote J, Deschesnes F, Davis B, Strinich T, Howie K, Duong M, Watson RM, Renzi PM, O'Byrne, PM. | 2008 | Antisense therapy against CCR3 and the common beta chain attenuates allergen-induced eosinophilic responses |
American Journal of Respiratory and Critical Care Medicine |
| Duong M, Cockcroft D, Boulet L-P, Ahmed T, Iverson H, Atkinson D, Stahl E, Watson R, Davis B, Milo J, Gauvreau G, O'Byrne P. | 2008 |
Allergy |