Study methods

BRONCHOPROVOCATION

  • Inhaled allergen (PC20/PD20, early & late asthmatic responses)
  • Methacholine airway hyperresponsiveness
  • Inhaled mannitol (Aridol®)
  • Exercise-induced bronchoconstriction
  • Hypertonic saline
  • Capsaicin cough challenge

AIRWAY INFLAMMATION MEASUREMENTS

  • Sputum induction (cell counts by microscopy or flow cytometry)
  • Bronchoscopy
  • Blood sampling
  • Fractional exhaled nitric oxide
  • Bone marrow aspirate
  • Skin prick test
  • Intradermal allergen challenge


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